Hypertension from chronic central sodium chloride in mice is mediated by the ouabain-binding site on the Na,K-ATPase α₂-isoform.

@article{Huysse2011HypertensionFC,
  title={Hypertension from chronic central sodium chloride in mice is mediated by the ouabain-binding site on the Na,K-ATPase α₂-isoform.},
  author={James W Van Huysse and Iva Dostanic and Jerry B. Lingrel and Xiaohong Hou and Hengwei Wu},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2011},
  volume={301 5},
  pages={H2147-53}
}
A chronic increase in the concentration of sodium chloride in the cerebrospinal fluid (CSF) (↑CSF [NaCl]) appears to be critically important for the development of salt-dependent hypertension. In agreement with this concept, increasing CSF [NaCl] chronically by intracerebroventricular (icv) infusion of NaCl-rich artificial CSF (aCSF-HiNaCl) in rats produces hypertension by the same mechanisms (i.e., aldosterone-ouabain pathway in the brain) as that produced by dietary sodium in salt-sensitive… CONTINUE READING
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