Hypertension-enhanced monocyte adhesion in experimental atherosclerosis.

  title={Hypertension-enhanced monocyte adhesion in experimental atherosclerosis.},
  author={B I Tropea and Philip Huie and John P Cooke and Phil S Tsao and Richard K. Sibley and Christopher K. Zarins},
  journal={Journal of vascular surgery},
  volume={23 4},
PURPOSE Hypertension is a known clinical risk factor for atherosclerosis. In experimental atherosclerosis, monocyte adhesion to the endothelial surface is enhanced and is considered to be an important early stage in plaque formation. We tested the hypothesis that hypertension enhances monocyte adhesion in experimental atherosclerosis. METHODS Twenty-two New Zealand White rabbits were fed an atherogenic diet for 3 weeks to induce plaque formation. Aortic coarctation was created in eight… CONTINUE READING