Hypertension during vascular endothelial growth factor inhibition: focus on nitric oxide, endothelin-1, and oxidative stress.

@article{Lankhorst2014HypertensionDV,
  title={Hypertension during vascular endothelial growth factor inhibition: focus on nitric oxide, endothelin-1, and oxidative stress.},
  author={Stephanie Lankhorst and Mari{\"e}tte H. W. Kappers and Joep H. M. van Esch and A. H. Jan Danser and Anton H. van den Meiracker},
  journal={Antioxidants & redox signaling},
  year={2014},
  volume={20 1},
  pages={135-45}
}
SIGNIFICANCE Angiogenesis inhibition with humanized antibodies targeting vascular endothelial growth factor (VEGF) or orally active small tyrosine kinase inhibitors targeting VEGF receptors has become an established treatment modality for various forms of cancer. A common side effect of angiogenesis inhibition is the development of sometimes severe hypertension, which simultaneously appears to be predictive for a favorable antitumor response. RECENT ADVANCES Since VEGF increases the… CONTINUE READING
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