Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice.

@article{Chen2001HypertensionDN,
  title={Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice.},
  author={Jinhui Chen and Peter Jan Kuhlencordt and Joshua M Astern and Robert Gyurko and Paul Lee Huang},
  journal={Circulation},
  year={2001},
  volume={104 20},
  pages={
          2391-4
        }
}
BACKGROUND Apolipoprotein E (apoE)/endothelial nitric oxide synthase (eNOS) double knockout (DKO) mice demonstrate accelerated atherosclerosis and develop abdominal aortic aneurysms and aortic dissection, suggesting a role for eNOS in suppressing atherogenesis. To test whether accelerated atherosclerosis and aortic aneurysms were due to hypertension, we administered hydralazine to male apoE/eNOS DKO mice to reduce blood pressure. METHODS AND RESULTS Male apoE/eNOS DKO mice were treated with… CONTINUE READING

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Role of endogenous nitric oxide in progression of atherosclerosis in apolipoprotein E-deficient mice

K Kauser, V da Cunha, R Fitch
  • Am J Physiol
  • 2000

Elevated blood pressures in mice lacking endothelial nitric oxide synthase.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1996

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