Hypertension associated with therapies to treat arthritis and pain.

  title={Hypertension associated with therapies to treat arthritis and pain.},
  author={William B White},
  volume={44 2},
Cyclooxygenase-2 (COX-2) inhibitors have become a widely used class of agents for the treatment of arthritis and pain because of their improved gastrointestinal safety and tolerability profile compared with the nonselective NSAIDs.1,2 During the past 4 years, the effects of these agents on destabilization of blood pressure (BP) has become a concern that has led to substantial research and controversy. COX inhibition is associated with antinatriuretic and vasoconstrictor effects mediated through… CONTINUE READING


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