Hypertension and impairment of endothelium-dependent relaxation of arteries from spontaneously hypertensive and L-NAME-treated Wistar rats.

@article{Sekiguchi2001HypertensionAI,
  title={Hypertension and impairment of endothelium-dependent relaxation of arteries from spontaneously hypertensive and L-NAME-treated Wistar rats.},
  author={Fumiko Sekiguchi and Yoshimasa Miyake and Akiko Y Hirakawa and Tomohiro Nakahira and Michiyo Yamaoka and Keiichi Shimamura and Kazuo Yamamoto and Satoru Sunano},
  journal={Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi},
  year={2001},
  volume={37 2},
  pages={67-79}
}
Effects of chronic treatment of normotensive Wistar rats with N(omega)-nitro-L-arginine methyl ester (L-NAME) on blood pressure and on endothelium-dependent relaxation of the aorta, carotid and iliac arteries were studied. The endothelium-dependent relaxation was compared in arteries from normotensive Wistar Kyoto rats (WKY) and genetically hypertensive rats (stroke-prone spontaneously hypertensive rats, SHRSP). Chronic treatment of normotensive Wistar rats with L-NAME caused an elevation of… CONTINUE READING

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