Hypertension and ageing impair acetylcholine-induced vasodilation in rats.

OBJECTIVE To investigate the influence of hypertension and ageing on the in vivo effect of acetylcholine on blood pressure and regional vascular conductance and the inhibitory effect of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis, on the effects of acetylcholine. METHODS Male spontaneously hypertensive rats (SHR) and Wistar… CONTINUE READING