Hypertension and RhoA/Rho-kinase signaling in the vasculature: highlights from the recent literature.

@article{Lee2004HypertensionAR,
  title={Hypertension and RhoA/Rho-kinase signaling in the vasculature: highlights from the recent literature.},
  author={Dexter L. Lee and Robert Clinton Webb and Liming Jin},
  journal={Hypertension},
  year={2004},
  volume={44 6},
  pages={796-9}
}
Under normal conditions, contractile activity in vascular smooth muscle is initiated by either receptor activation (norepinephrine, angiotensin II, etc.) or by a stretch-activated mechanism. After this activation, several signaling pathways can initiate a Ca2+-calmodulin interaction to stimulate phosphorylation of the light chain of myosin. Ca2+ sensitization of the contractile proteins is signaled by the RhoA/Rho-kinase pathway to inhibit the dephosphorylation of the light chain by myosin… CONTINUE READING