Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.

@article{Abe1998HypertensionHA,
  title={Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.},
  author={Hitoshi Abe and Nobuhiro Yamada and Kentaroh Kamata and Tomoyuki Kuwaki and Miho Shimada and Jun-ichi Osuga and Futoshi Shionoiri and Nobuo Yahagi and Takashi Kadowaki and Hiroyuki Tamemoto and Satoru Ishibashi and Yoshio Yazaki and Masatoshi Makuuchi},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={101 8},
  pages={1784-8}
}
Insulin resistance is often associated with atherosclerotic diseases in subjects with obesity and impaired glucose tolerance. This study examined the effects of insulin resistance on coronary risk factors in IRS-1 deficient mice, a nonobese animal model of insulin resistance. Blood pressure and plasma triglyceride levels were significantly higher in IRS-1 deficient mice than in normal mice. Impaired endothelium-dependent vascular relaxation was also observed in IRS-1 deficient mice. Furthermore… CONTINUE READING