Hypertension, angiotensin, and stroke: beyond blood pressure.

@article{Iadecola2004HypertensionAA,
  title={Hypertension, angiotensin, and stroke: beyond blood pressure.},
  author={C Iadecola and Philip B. Gorelick},
  journal={Stroke},
  year={2004},
  volume={35 2},
  pages={348-50}
}
Hypertension (HTN) is a major risk factor for all stroke subtypes, infarction as well as hemorrhage.1,2 Evidence from clinical trials shows that control of blood pressure (BP) leads to a substantially lower risk of stroke.3 HTN exerts detrimental actions on the cerebral circulation that play a critical role in its ability to promote cerebrovascular diseases. Angiotensin II (Ang II) is a key mediator by which HTN exerts its deleterious vascular effects. Recent findings raise the possibility that… CONTINUE READING

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Angiotensin II alters neurovascular coupling via production of reactive oxygen species

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