Hypertension, angiotensin, and stroke: beyond blood pressure.

  title={Hypertension, angiotensin, and stroke: beyond blood pressure.},
  author={C Iadecola and Philip B. Gorelick},
  volume={35 2},
Hypertension (HTN) is a major risk factor for all stroke subtypes, infarction as well as hemorrhage.1,2 Evidence from clinical trials shows that control of blood pressure (BP) leads to a substantially lower risk of stroke.3 HTN exerts detrimental actions on the cerebral circulation that play a critical role in its ability to promote cerebrovascular diseases. Angiotensin II (Ang II) is a key mediator by which HTN exerts its deleterious vascular effects. Recent findings raise the possibility that… CONTINUE READING


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Angiotensin II alters neurovascular coupling via production of reactive oxygen species

  • K Kazama, J Anrather, G Wang, K Frys, C. Iadecola
  • J Cereb Blood Flow Metab. 2003;23(suppl 1):83
  • 2003

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