Hyperstimulation Pancreatitis in Mice Induced by Cholecystokinin Octapeptide, Caerulein, and Novel Analogues: Effect of Molecular Structure on Potency

@article{Shorrock1991HyperstimulationPI,
  title={Hyperstimulation Pancreatitis in Mice Induced by Cholecystokinin Octapeptide, Caerulein, and Novel Analogues: Effect of Molecular Structure on Potency},
  author={K. Shorrock and B. Austen and J. Hermon-Taylor},
  journal={Pancreas},
  year={1991},
  volume={6},
  pages={404–406}
}
Acute pancreatic oedema with hyperamylasaemia was induced in mice by subcutaneous administration of cholecystokinin octapeptide (CCK8). Comparison with effect of caerulein showed that cholecystokinin is less potent in vivo. To investigate the observed difference in response, threonine3 CCKS and methionine5 caerulein were synthesised and evaluated. Comparison of these peptides suggests that difference in bioactivity is related to possession of extra N-terminal residues rather than substitution… Expand
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Hyperstimulation pancreatitis induced by CCK8: Differing dose-response characteristics to caerulein [Abstract
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