Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716.

@article{Hilairet2003HypersensitizationOT,
  title={Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716.},
  author={Sandrine Hilairet and Monsif Bouaboula and Dominique Carri{\`e}re and G{\'e}rard Le Fur and Pierre Casellas},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 26},
  pages={
          23731-7
        }
}
In the present study, we observed evidence of cross-talk between the cannabinoid receptor CB1 and the orexin 1 receptor (OX1R) using a heterologous system. When the two receptors are co-expressed, we observed a major CB1-dependent enhancement of the orexin A potency to activate the mitogen-activated protein kinase pathway; dose-responses curves indicated a 100-fold increase in the potency of orexin-mediated mitogen-activated protein kinase activation. This effect required a functional CB1… CONTINUE READING
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