Hypersensitivity reactions to fluoroquinolones

  title={Hypersensitivity reactions to fluoroquinolones},
  author={Kathrin Scherer and Andreas J. Bircher},
  journal={Current Allergy and Asthma Reports},
Fluoroquinolone antibiotics cause immediate and delayed hypersensitivity reactions, and may also affect internal organs and circulating blood cells. The underlying pathomechanisms are only partly understood. The extent of cross-reactivity among different quinolones depends on the type of clinical manifestation and its underlying mechanism. Despite recent advances, reliable diagnostic tests are still lacking. Recent studies have shown quinolone-specific IgE in vitro in more than 50% of patients… 

Hypersensitivity Reactions to Fluoroquinolones

Drug provocation testing is currently the best method to establish diagnosis of allergy to FQs; however, it carries certain risks and should be avoided for cases with a history of severe reactions and to find alternative treatments.

Quinolones-induced hypersensitivity reactions.

Quinolone-Induced Anaphylaxis

This review critically analyzed the existing data on quinolone allergy, highlighting the recent advances in its diagnosis and management and further studies are needed to increase the knowledge in the field and to improve patients’ care.

Update on Quinolone Allergy

Allergic reactions to quinolones can be immediate or delayed, being anaphylaxis and maculopapular exanthema respectively the most frequent clinical entities.

Hypersensitivity Reactions to Non-Beta Lactam Antibiotics

In vivo and in vitro diagnostic tests and management strategies for NBL HRs are discussed in detail to provide guidance for daily clinical practice.

Trends in hypersensitivity drug reactions: more drugs, more response patterns, more heterogeneity.

Five well-defined clinical entities, the most common of which is NSAID-induced urticaria/angioedema, have been proposed in a new consensus classification.

Basophil Reactivity as Biomarker in Immediate Drug Hypersensitivity Reactions—Potential and Limitations

The suitability of BAT as biomarker for the diagnosis of immediate drug-induced hypersensitivity reactions is evaluated and influencing factors like the selection of stimulants or of the identification and activation markers, the stimulation protocol, gating strategies, and cut-off definition are addressed in this overview on BAT performance.

Hypersensitivity to fluoroquinolones

In patients allergic to moxifloxacin with anaphylactic shock, the authors have observed an increase in the percentage of cells that upregulate CD203c, whereas patients withAnaphylaxis preferentially upregulates CD63.

Hypersensitivity reactions to non‐betalactam antibiotics in children: An extensive review

  • S. KuyucuF. Mori K. Brockow
  • Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2014
A standardized diagnostic approach and management strategy should be developed and employed for pediatric patients in the evaluation of suspected HSRs to NBLAs, some of which may be critical and unreplaceable in certain clinical situations.



Detection of specific IgE to quinolones.

Tolerability of Fluoroquinolone Antibiotics

The main elements of their adverse reaction profile were predictable from human experience with precursor naphthyridines and quinolones, and from toxicological studies in animals, and postmarketing surveillance studies and prescription event monitoring have largely confirmed the limited adverse reactions defined during clinical trials.

Cross‐reactivity between quinolones

Avoidance of any quinolone should be recommended to any patients who has suffered an allergic reaction to one of these drugs, because cross‐reactivity between quInolones seems to be very important.

Nonirritating intradermal skin test concentrations for commonly prescribed antibiotics.

Chemistry of drug allergenicity

Progress in identifying allergenic determinants is reviewed together with the still inadequately understood subject of IgE antibody recognition of quinolone antibacterial agents.

Hypersensitivity and Anaphylactoid Reactions to Ciprofloxacin

As with trimethoprim/sulfamethoxazole, HIV-infected people treated with ciprofloxacin may be at special risk for hypersensitivity reactions.

Quinolone photoallergy: photosensitivity dermatitis induced by systemic administration of photohaptenic drugs.

  • Y. Tokura
  • Biology, Medicine
    Journal of dermatological science
  • 1998

Relevance of skin tests with drugs in investigating cutaneous adverse drug reactions

Skin tests with drugs can be of value in investigating patients who have developed cutaneous adverse drug reactions (CADR), but their specificity and relevance remain to be determined. A

A new respiratory fluoroquinolone, oral gemifloxacin: a safety profile in context.

Flush induced by fluoroquinolones in canine skin

Results indicate that the flush induced by fluoroquinolones is mediated by histamine release from canine cutaneous mast cells and H2-receptor stimulation.