Hypersensitivity reactions to L-asparaginase do not impact on the remission duration of adults with acute lymphoblastic leukemia

@article{Larson1998HypersensitivityRT,
  title={Hypersensitivity reactions to L-asparaginase do not impact on the remission duration of adults with acute lymphoblastic leukemia},
  author={R E Larson and MH Fretzin and R M Dodge and C F Schiffer},
  journal={Leukemia},
  year={1998},
  volume={12},
  pages={660-665}
}
Among its multiple toxic effects, L-asparaginase induces allergic reactions that may reduce its biological effect. The impact of hypersensitivity reactions on the duration of leukemia-free survival (LFS) was assessed in adults with newly diagnosed acute lymphoblastic leukemia (ALL) receiving intensive multi-agent chemotherapy. In CALGB study 8811 (Blood 1995; 85: 2025–2037), 197 adults were scheduled to receive 14 doses of Escherichia coli L-asparaginase (6000 U/m2 SC) during 7 of the first 12… CONTINUE READING

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