Hypersensitivity reactions and deaths associated with intravenous iron preparations.

  title={Hypersensitivity reactions and deaths associated with intravenous iron preparations.},
  author={George R. Bailie and John David Clark and Christi E Lane and Peter L Lane},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={20 7},
BACKGROUND Parenteral iron therapy is an accepted adjunctive management of anaemia in kidney disease. Newer agents may have fewer severe hypersensitivity adverse events (AE) compared with iron dextrans (ID). The rate of type 1 AE to iron sucrose (IS) and sodium ferric gluconate (SFG) relative to ID is unclear. We used the US Food and Drug Administration's Freedom of Information (FOI) surveillance database to compare the type 1 AE profiles for the three intravenous iron preparations available in… CONTINUE READING
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