Hypersensitivity of malignant hyperthermia-susceptible swine skeletal muscle to caffeine is mediated by high resting myoplasmic [Ca2+ ].

@article{Lpez2000HypersensitivityOM,
  title={Hypersensitivity of malignant hyperthermia-susceptible swine skeletal muscle to caffeine is mediated by high resting myoplasmic [Ca2+ ].},
  author={Jos{\'e} Rafael L{\'o}pez and Jaime P. Contreras and Nancy Linares and Paul D. Allen},
  journal={Anesthesiology},
  year={2000},
  volume={92 6},
  pages={1799-806}
}
BACKGROUND Malignant hyperthermia (MH) is an inherited pharmacogenetic syndrome that is triggered by halogenated anesthetics and/or depolarizing muscle relaxants. MH-susceptible (MHS) skeletal muscle has been shown to be more sensitive to caffeine-induced contracture than muscle from nonsusceptible (MHN) subjects and is the basis for the most commonly used clinical diagnostic test to determine MH susceptibility. METHODS We studied the effects of caffeine on myoplasmic free calcium… CONTINUE READING
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