Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks.

Abstract

We have studied the intrinsic radiosensitivity, repair of potentially lethal damage (PLD) and the repair rate of radiation-induced DNA double-strand breaks (DSB) in 11 non-transformed human fibroblast cell lines, four of which were homozygous for the A-T mutation and two that were heterozygous (A-TH). All the experiments were done on cells in plateau phase… (More)

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@article{Foray1997HypersensitivityOA, title={Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks.}, author={Nicolas Foray and Anne Priestley and Ghazi A Alsbeih and Christophe Badie and Emily Capulas and Colin F. Arlett and Edmond P. Malaise}, journal={International journal of radiation biology}, year={1997}, volume={72 3}, pages={271-83} }