Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

  title={Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.},
  author={Raymond H. Kim and Patrice D Smith and Hossein Aleyasin and Shawn P Hayley and Matthew Paul Mount and Scott Pownall and Andrew C. Wakeham and Annick J You-Ten and Suneil K Kalia and Patrick Horne and David Westaway and Andres M. Lozano and Hymie Anisman and David S. Park and Tak W Mak},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 14},
Mutations of the DJ-1 (PARK7) gene are linked to familial Parkinson's disease. We used gene targeting to generate DJ-1-deficient mice that were viable, fertile, and showed no gross anatomical or neuronal abnormalities. Dopaminergic neuron numbers in the substantia nigra and fiber densities and dopamine levels in the striatum were normal. However, DJ-1-/- mice showed hypolocomotion when subjected to amphetamine challenge and increased striatal denervation and dopaminergic neuron loss induced by… CONTINUE READING
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