Hypersensitivity Reactions to Vaccine Components

  title={Hypersensitivity Reactions to Vaccine Components},
  author={Noushin Heidary and David Elliott Cohen},
&NA; Vaccines are responsible for the control of many infectious diseases that were once common in the United States, including polio, measles, diphtheria, pertussis (whooping cough), rubella (German measles), mumps, tetanus, and Haemophilus influenzae type b. National efforts to generate collaboration between federal, state, and local governments and public and private health care providers have resulted in record high levels of vaccination coverage in the United States. The high rate of US… 

Hypersensitivity Reactions to Vaccine Constituents: A Case Series and Review of the Literature

The goals were to inform physicians on the variety of hypersensitivity reactions to common vaccines and to provide information on the choice of vaccines in patients with suspected hypersensitivity.

Local Vaccine Site Reactions and Contact Allergy to Aluminum

Although rare, aluminum contact allergy after routine immunization can occur and should be considered in the differential diagnosis of persistent subcutaneous nodules after vaccination, and contact allergy testing confirmed sensitivity to aluminum.

[Bordetella pertussis lipooligosaccharide-derived neoglycoconjugates - new components of pertussis vaccine].

The epidemiologic situation of pertussis in the past decades showing the ineffectiveness of contemporary, acellular pertussedis vaccines is discussed and the important role of bactericidal antibodies against lipooligosaccharide was indicated in effective immune defense.

Innovative vaccine production technologies: The evolution and value of vaccine production technologies

This review paper provides an overview of innovative technologies designed to produce bacterial, viral, recombinant subunit, and polysaccharide vaccines, as well as combination vaccines. Advances in

Aluminium in Allergies and Allergen immunotherapy

The adjuvant and safety profile of aluminium adjuvant in allergy vaccines are discussed, as well as the need for putting modern delivery systems and adjuvants on the fast track.

Known Vaccine-Associated Adverse Events

The most beneficial worldwide health interventions in the twentieth century include vaccines. Despite and in part because of their success, adverse events following immunization (AEFIs) are

Thimerosal and Other Vaccine Additives

This chapter reviews some of the more common or controversial vaccine excipients, and related information regarding safety concerns, which have been a significant source of misunderstanding, and misinformation.

DPT vaccine‐induced lipoatrophy: an observational study

Diphtheria Pertussis Tetanus vaccine is generally safe and well tolerated and injection site lipoatrophy has not been reported earlier.

An antibody response to cholera toxin, but not soy proteins, following oral administration of adjuvanted soybean formulations

It is demonstrated that oral soybean-based vaccine formulations do not induce detectable antibody responses to soy proteins, even when the formulations contain a potent mucosal adjuvant, which underscores the safety of oral vaccine formulations which might contain soy proteins as a component.



MMR vaccine and neomycin allergy.

The experience with the following patient suggests that hypersensitivity to these additives found in the MMR vaccine, especially neomycin, may be a factor in documented reactions in individuals without egg allergy.

Thiomersal allergy and vaccination reactions

Suggesting that thiomersal hypersensitivity wits not associated with an increased risk of vaccination reactions, however, individual cases of severe reactions to thiomeric demonstrate a need for vaccines with an alternative preservative.

Vaccine allergy: diagnosis and management.

A probable role for vaccines containing thimerosal in thimerosal hypersensitivity

From patch testing in humans and animal experiments, it is suggested that 0.01% thimerosal in vaccines can sensitize children, and that hypersensitivity toThimerosal is due to the throsaticylic part of the molecule and correlates with photosensitivity to piroxicam.

Vaccination despite thimerosal sensitivity

It is concluded that sensitization had occurred through vaccines, but those amounts of thimerosal delivered i.m. are not sufficient to elicit clinical symptoms, and patch‐test Positivity toThimerosal thus represents no contra‐indication to i.M immunization with Thimerosal‐containing vaccines.

Allergic contact dermatitis from mercury antiseptics and derivatives: study protocol of tolerance to intramuscular injections of thimerosal.

Vaccination with thimerosal is relatively safe, even for individuals with delayed type hypersensitivity to this chemical, since more than 90% of allergic patients tolerated intramuscular challenge tests withThimerosal.

Thimerosal in the detection of clinically relevant allergic contact reactions.

It is proposed that either ethyleneurea/melamine formaldehyde or bacitracin would be more useful than thimerosal as a commercially available screening allergen.

Influence of Temperature on the Efficacy of 2-Phenoxyethanol as a Preservative for Adsorbed Diphtheria-Purified Pertussis-Tetanus Combined Vaccine

Two antimicrobial preservatives were compared in adsorbed diphtheria-purified pertussis-tetanus combined vaccine and data suggest that 2-PE has weaker antimicrobial activity than Thimerosal against yeast and fungi in DPT vaccine at low temperatures.

Hypersensitivity to preservatives

Parabens, which the industry has sought to replace with “safer” alternatives, are still the most frequently used biocides in cosmetics and appear to be far less sensitizing than most of the newer agents.

Persistent subcutaneous nodules in patients hyposensitized with aluminum-containing allergen extracts.

A pure histiocytic foreign body reaction was observed in early lesions, and a delayed hypersensitivity granulomatous reaction was seen in older lesions, suggesting aluminum-free preparations should be used in patients in whom these nodules develop.