Hyperreninemic hypoaldosteronism in the critically ill: a new entity.

  title={Hyperreninemic hypoaldosteronism in the critically ill: a new entity.},
  author={Robert D. Zipser and M W Davenport and Kimberly L Martin and Michael L. Tuck and Nancy E Warner and R R Swinney and Catherine L. Davis and Richard Horton},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={53 4},
To define the changes in adrenal gland function during critical illness, we evaluated 28 severely ill patients with persistent hypotension who were hospitalized in a medical intensive care unit. The patients had increased plasma cortisol (mean +/- SE, 40.1 +/- 10.1 micrograms/dl). PRA was increased in all subjects (21.6 +/- 7.2 ng/ml.h); however, the plasma aldosterone concentration was inappropriately low in 18 of the subjects, with values ranging from 1-9 ng/dl, despite normal serum potassium… CONTINUE READING
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