Hyperprolactinemia in men

@article{Rosa2007HyperprolactinemiaIM,
  title={Hyperprolactinemia in men},
  author={Michele De Rosa and Stefano Zarrilli and Antonella di Sarno and Nicola Milano and Maria Gaccione and Bartolomeo Boggia and Gaetano Lombardi and Annamaria Colao},
  journal={Endocrine},
  year={2007},
  volume={20},
  pages={75-82}
}
Hyperprolactinemia induces hypogonadism by inhibiting gonadotropin-releasing hormone pulsatile secretion and, consequently, follicle-stimulating hormone, luteinizing hormone, and testosterone pulsatility. This leads to spermatogenic arrest, impaired motility, and sperm quality and results in morphologic alterations of the testes similar to those observed in prepubertal testes. Men with hyperprolactinemia present more frequently with a macroadenoma than a microadenoma. Symptoms directly related… 
Hyperprolactinemia and prolactinoma.
  • J. Romijn
  • Medicine
    Handbook of clinical neurology
  • 2014
TLDR
The cardiac adverse effects of dopamine agonists reported in Parkinson's disease are not of clinical concern in the treatment of prolactinomas, which are treated with much lower doses, and there is uncertainty with respect to the dose and duration of cabergoline treatment.
Prevalence of Hyperprolactinemia and Clinically Apparent Prolactinomas in Men Undergoing Fertility Evaluation.
TLDR
The overall prevalence of prolactinoma in the cohort of men undergoing fertility evaluation was 35-fold higher than the prevalence in the general male population.
Prolactinomas in males: any differences?
TLDR
Compared to other pituitary adenomas, secreting and non-secreting, men with prolactinomas will usually respond to medical treatment with no need for any additional treatment.
Prolactin-to-Testosterone Ratio Predicts Pituitary Abnormalities in Mildly Hyperprolactinemic Men with Symptoms of Hypogonadism.
TLDR
The prolactin-to-testosterone ratio is the best independent predictor of finding a pituitary abnormality on magnetic resonance imaging, though sensitivity improves by referencing additional serologic parameters.
Prolactin in men's health and disease
TLDR
Detecting and treating elevated PRL may not only improve infertility and hypogonadism but also have a positive effect on the metabolic profile of patient and control of glycemic control and metabolic profile – an important advantage considering dramatic and worldwide increase in obesity and diabetes.
[Hyperprolactinemia: causes, diagnosis, and treatment].
TLDR
It should be stressed that finding of elevated PRL serum concentrations constitute the beginning of diagnostic procedure and, after exclusion of physiologic, pharmacologic, and other organic causes of increased PRL levels, should be followed by detailed diagnosis including MRI.
Evaluation of therapy with cabergoline in men with macroprolactinoma
Introduction: Pituitary gland adenomas producing prolactin are one of the commonest hormonally active tumours. Phar‐ macological treatment using of dopamine receptors agonists is the therapy of
Persistent bone impairment despite long-term control of hyperprolactinemia and hypogonadism in men and women with prolactinomas
TLDR
It was found that persistent hyperprolactinemia and male sex were independent risk factors for long-term bone impairment and bone impairment as “end organ” reflects the full range of the disease and could become a surrogate marker for the severity of long-lasting hyper Prolactinoma and associated hypogonadism.
Hormonal causes of male sexual dysfunctions and their management (hyperprolactinemia, thyroid disorders, GH disorders, and DHEA).
TLDR
Although dehydroepiandrosterone (DHEA) and its sulfate have been implicated in a broad range of biological derangements, controlled trials have shown that DHEA administration is not useful for improving male sexual function.
The Effect of Hyperprolactinemia on Semen Parameters
TLDR
Although no significant association between the pro lactin level and semen parameters was detected, it is suggested that prolactin levels should be tested in patients with a sperm concentration of less than 10x10 6 /ml in light of literature data.
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References

SHOWING 1-10 OF 83 REFERENCES
Bromocriptine for infertile males with mild hyperprolactinemia: hormonal and spermatogenic effects.
TLDR
In infertile men who are mildly hyperprolactinemic, bromocriptine administration does not improve semen analysis, although it does normalize the PRL.
HYPERPROLACTINAEMIA AND HYPOGONADISM IN MEN: RESPONSE TO EXOGENOUS GONADOTROPHINS
TLDR
In all three patients, despite the persistence of hyperprolactinaemia, serum testosterone had risen to normal levels within 4–17 days after starting HCG and pharmacological doses of HCG induced testosterone secretion in all these three subjects.
[Leydig cell function in hyper- or hypoprolactinemic states in healthy men].
TLDR
It is concluded that prolactin plays an important role in the steroidogenesis of Leydig cells in normal men, as the response of gonadal steroids to the injections i.m. of 2000 UI of hCG was studied.
Hyperprolactinaemia among infertile patients and its effect on sperm functions
TLDR
Results suggest that hyperprolactinaemia, which does not cause symptoms, has little effect on the impairment of sperm functions, and measurement of serum prolactin in infertile men could be justified, however, for early detection of pituitary adenomas.
ALTERED PULSATILE SECRETION OF LUTEINIZING HORMONE IN HYPOGONADAL MEN WITH HYPERPROLACTINAEMIA
TLDR
The data suggest that a major abnormality in hyperprolactinaemic men with hypogonadism is a disorder of the neuroregulatory mechanism for pulsatile gonadotrophin‐releasing hormone secretion.
HYPERPROLACTINAEMIA IN MALES WITH AND WITHOUT PITUITARY MACROADENOMAS
TLDR
In the macroadenoma group bromocriptine restored serum Prolactin levels in 13 of the 16 and serum testosterone and potency in 5, whereas in the non-tumour group it restored serum prolactinLevels in all 10 and serumosterone and potencyIn 9, the group with pituitary mac roadenomas was older and had tolerated impotence for longer.
Chronic treatment with CV 205-502 restores the gonadal function in hyperprolactinemic males.
TLDR
The treatment with CV 205-502 normalizing PRL levels improves gonadal and sexual function and fertility in males with prolactinoma, providing good tolerability and excellent patient compliance to medical treatment.
Cabergoline treatment rapidly improves gonadal function in hyperprolactinemic males: a comparison with bromocriptine.
TLDR
The treatment with CAB normalized PRL levels, improving gonadal and sexual function and fertility in males with prolactinoma, earlier than did BRC treatment, providing good tolerability and excellent patient compliance to medical treatment.
Male hyperprolactinemia:effects on fertility.
TLDR
The use of bromocriptine with human menopausal gonadotropic and human chorionic gonadotropin was beneficial in treating hypog onadotropic hypogonadism with hyperprolactinemia.
Hypogonadism of male prolactinomas: Relation to pulsatile secretion of LH: Hypogonadisms des Mannes mit Prolaktinomen: Beziehungen zur pulsatilen LH‐Sekretion
TLDR
The hypothalamus and pituitary function of male prolactinomas were well preserved, in spite of higher serum PRL levels and larger tumor size than those reported in females.
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