Hyperproduction of alpha-toxin by Staphylococcus aureus results in paradoxically reduced virulence in experimental endocarditis: a host defense role for platelet microbicidal proteins.

@article{Bayer1997HyperproductionOA,
  title={Hyperproduction of alpha-toxin by Staphylococcus aureus results in paradoxically reduced virulence in experimental endocarditis: a host defense role for platelet microbicidal proteins.},
  author={Arnold S Bayer and Mar{\'i}a Dolores Burguete Ramos and Barbara E. Menzies and Michael R Yeaman and A J Shen and Ambrose L Cheung},
  journal={Infection and immunity},
  year={1997},
  volume={65 11},
  pages={
          4652-60
        }
}
Staphylococcal alpha-toxin targets several cell types which are important components of cardiac vegetations in endocarditis, including platelets, erythrocytes, and endothelial cells. We evaluated the in vivo role of Staphylococcus aureus alpha-toxin in experimental endocarditis by using isogenic strains differing in the capacity to produce functional alpha-toxin, including 8325-4 (wild-type strain), DU-1090 (a mutant strain with allelic replacement of the alpha-toxin gene [hla]), DU1090(pH35L… CONTINUE READING

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