Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain.


KCC2 is the neuron-specific member of the of K(+)-Cl(-) cotransporter gene family. It is also the only member of its family that is active under physiologically normal conditions, in the absence of osmotic stress. By extruding Cl(-) from the neuron under isotonic conditions, this transporter maintains a low concentration of neuronal Cl(-), which is… (More)
DOI: 10.1523/JNEUROSCI.6089-11.2012


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