Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain.

@article{Acton2012HyperpolarizingGT,
  title={Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain.},
  author={Brooke A. Acton and Vivek Mahadevan and Adrianna Mercado and Pavel Uvarov and Yanli Ding and Jessica C Pressey and Matti S Airaksinen and David B. Mount and Melanie A Woodin},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 25},
  pages={8746-51}
}
KCC2 is the neuron-specific member of the of K(+)-Cl(-) cotransporter gene family. It is also the only member of its family that is active under physiologically normal conditions, in the absence of osmotic stress. By extruding Cl(-) from the neuron under isotonic conditions, this transporter maintains a low concentration of neuronal Cl(-), which is essential for fast inhibitory synaptic transmission by GABA and glycine in the mature nervous system. The other members of this K(+)-Cl… CONTINUE READING
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