Hyperpolarized 13C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco

@article{Crane2020Hyperpolarized1M,
  title={Hyperpolarized 13C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco},
  author={Jason C. Crane and Jeremy W. Gordon and Hsin-Yu Chen and A.W. Autry and Yan Li and Marram P. Olson and John Kurhanewicz and Daniel B. Vigneron and P. Larson and Duan Xu},
  journal={NMR in Biomedicine},
  year={2020},
  volume={34}
}
Abstract 
Characterization of serial hyperpolarized 13C metabolic imaging in patients with glioma
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TLDR
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TLDR
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TLDR
Testing whether metabolic imaging with hyperpolarized MRI could detect changes in tumor progression faster than conventional anatomic MRI in patient-derived glioblastoma murine models found it to be more sensitive than conventional MRI.
Advanced methodology for in vivo magnetic resonance spectroscopy
TLDR
This Special Issue of NMR in Biomedicine is now placed on advanced methodology that largely goes beyond the established techniques implemented on clinical scanners and aims at either the most robust metabolic information using the latest acquisition and processing technology or the most sensitive detection among intricate metabolic measures linked to underlying biochemical processes complementing structural and functional measures afforded by MRI.
Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [13 C,15 N2 ]urea + [1-13 C]pyruvate simultaneous perfusion and metabolic imaging.
TLDR
The in vivo feasibility of a 3D stack-of-spiral balanced steady-state free precession urea sequence, interleaved with a metabolite-specific gradient echo sequence for pyruvate and metabolic products, is developed and validated for improving the SNR and spatial resolution of the first hyperpolarized 13 C-MRI human study.
Whole-Abdomen Metabolic Imaging of Healthy Volunteers Using Hyperpolarized [1-13 C]pyruvate MRI.
TLDR
Whole-abdomen coverage with hyperpolarized carbon-13 MRI was feasible despite technical challenges, and metabolite energetics in the abdomen compiled for healthy volunteers can be used to design larger clinical trials in patients with metabolic diseases.
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