Hyperpolarized 13C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco

  title={Hyperpolarized 13C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco},
  author={Jason C. Crane and Jeremy W. Gordon and Hsin-Yu Chen and A.W. Autry and Yan Li and Marram P. Olson and John Kurhanewicz and Daniel B. Vigneron and P. Larson and Duan Xu},
  journal={NMR in Biomedicine},
Characterization of serial hyperpolarized 13C metabolic imaging in patients with glioma
Denoising of hyperpolarized 13C MR images of the human brain using patch‐based higher‐order singular value decomposition
To improve hyperpolarized 13C (HP‐13C) MRI by image denoising with a new approach, patch‐based higher‐order singular value decomposition (HOSVD).
Specialized computational methods for denoising, B1 correction, and kinetic modeling in hyperpolarized 13C MR EPSI studies of liver tumors
To develop a novel post‐processing pipeline for hyperpolarized (HP) 13C MRSI that integrates tensor denoising and B1+ correction to measure pyruvate‐to‐lactate conversion rates (kPL) in patients with
Comprehensive Literature Review of Hyperpolarized Carbon-13 MRI: The Road to Clinical Application
This review provides a comprehensive assessment of the development of hyperpolarized (HP) carbon-13 metabolic MRI from the early days to the present with a focus on clinical applications, and concludes that the workflow for hyperPolarized carbon- 13 MRI is the limiting factor.
Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging
The advantages of hyperpolarized carbon-13 MR MR metabolic imaging are presented, considerations in clinical translations are described, and current human brain applications are summarized.
Pilot Study of Hyperpolarized 13C Metabolic Imaging in Pediatric Patients with Diffuse Intrinsic Pontine Glioma and Other CNS Cancers
Investigation of the safety and tolerability of hyperpolarized carbon-13 (HP-13C) metabolic imaging in pediatric patients with brain tumors found it well-tolerated and demonstrated characteristic conversion to [1- 13C]lactate and [13C]bicarbonate in the brain.
Measuring the Metabolic Evolution of Glioblastoma throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance
Testing whether metabolic imaging with hyperpolarized MRI could detect changes in tumor progression faster than conventional anatomic MRI in patient-derived glioblastoma murine models found it to be more sensitive than conventional MRI.
Advanced methodology for in vivo magnetic resonance spectroscopy
This Special Issue of NMR in Biomedicine is now placed on advanced methodology that largely goes beyond the established techniques implemented on clinical scanners and aims at either the most robust metabolic information using the latest acquisition and processing technology or the most sensitive detection among intricate metabolic measures linked to underlying biochemical processes complementing structural and functional measures afforded by MRI.
Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [13 C,15 N2 ]urea + [1-13 C]pyruvate simultaneous perfusion and metabolic imaging.
The in vivo feasibility of a 3D stack-of-spiral balanced steady-state free precession urea sequence, interleaved with a metabolite-specific gradient echo sequence for pyruvate and metabolic products, is developed and validated for improving the SNR and spatial resolution of the first hyperpolarized 13 C-MRI human study.
Whole-Abdomen Metabolic Imaging of Healthy Volunteers Using Hyperpolarized [1-13 C]pyruvate MRI.
Whole-abdomen coverage with hyperpolarized carbon-13 MRI was feasible despite technical challenges, and metabolite energetics in the abdomen compiled for healthy volunteers can be used to design larger clinical trials in patients with metabolic diseases.


Translation of Carbon‐13 EPI for hyperpolarized MR molecular imaging of prostate and brain cancer patients
To develop and translate a metabolite‐specific imaging sequence using a symmetric echo planar readout for clinical hyperpolarized (HP) Carbon‐13 (13C) applications.
Development of a symmetric echo planar imaging framework for clinical translation of rapid dynamic hyperpolarized 13C imaging
To develop symmetric echo planar imaging (EPI) and a reference scan framework for hyperpolarized 13C metabolic imaging.
Development of methods and feasibility of using hyperpolarized carbon‐13 imaging data for evaluating brain metabolism in patient studies
The purpose of this study was to develop and implement experimental strategies for using [1‐13C]pyruvate to probe in vivo metabolism for patients with brain tumors and other neurological diseases.
Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1‐13C]pyruvate and 13C‐urea
To demonstrate the feasibility of imaging a bolus of co‐polarized [1‐13C]pyruvate and 13C‐urea to simultaneously assess both metabolism and perfusion in the rodent heart.
A comparison of coil combination strategies in 3D multi‐channel MRSI reconstruction for patients with brain tumors
The goal of this study was to find the most robust algorithm for a phase‐sensitive coil combination of 3D single‐cycle and lactate‐edited, multi‐channel H‐1 point‐resolved spectroscopy (PRESS)
ISMRM Raw data format: A proposed standard for MRI raw datasets
This work proposes the ISMRM Raw Data format as a common MR raw data format, which promotes algorithm and data sharing, and it is proposed that this format should be adopted by all MR researchers.
Joint spatial‐spectral reconstruction and k‐t spirals for accelerated 2D spatial/1D spectral imaging of 13C dynamics
To develop a novel imaging technique to reduce the number of excitations and required scan time for hyperpolarized 13C imaging.
A regional bolus tracking and real‐time B1 calibration method for hyperpolarized 13C MRI
The goal of this project was to develop a new approach using regional bolus tracking to trigger Bloch‐Siegert B1 mapping and real‐time B1 calibration based on regional B1 measurements, followed by dynamic imaging of hyperpolarized 13C metabolites in vivo.
Technique development of 3D dynamic CS‐EPSI for hyperpolarized 13C pyruvate MR molecular imaging of human prostate cancer
A new 3D dynamic carbon‐13 compressed sensing echoplanar spectroscopic imaging (EPSI) MR sequence is developed and tested in phantoms, animal models, and then in prostate cancer patients to image the metabolic conversion of hyperpolarized pyruvate to [1‐13C]lactate with whole gland coverage at high spatial and temporal resolution.
Investigation of analysis methods for hyperpolarized 13C‐pyruvate metabolic MRI in prostate cancer patients
The goal of this work was to develop and test analysis methods for improved quantification of this metabolic conversion from pyruvate to lactate, which is expected to increase in aggressive cancers.