Hyperpolarized [ 1-13 C ] acetylcarnitine as a tracer for cardiac metabolism

Introduction: Acetylcarnitine (ALCAR) is known to facilitate the influx and efflux of acetylgroups across the mitochondrial membrane and buffers an excess in acetylCoA in both cytosolic and mitochondrial compartments [1]. Acetylcarnitine is a necessary intermediate for mitochondrial acetate metabolism [2] and has been shown to easily cross the blood brain… (More)