Hyperpolarization-activated currents in presynaptic terminals of mouse cerebellar basket cells.

@article{Southan2000HyperpolarizationactivatedCI,
  title={Hyperpolarization-activated currents in presynaptic terminals of mouse cerebellar basket cells.},
  author={Andrew Paul Southan and N. P. Morris and Gary J Stephens and Brita Robertson},
  journal={The Journal of physiology},
  year={2000},
  volume={526 Pt 1},
  pages={
          91-7
        }
}
Using patch-clamp techniques, a hyperpolarization-activated current (I(h)) was recorded from synaptic terminals of mouse cerebellar basket cells. Ih was blocked quickly and reversibly by 2 mM Cs(+), and subtraction revealed a rapidly activating and deactivating I(h) current. Similar gating and block of presynaptic I(h) were also seen with the more selective inhibitor ZD 7288 (10 microM). The time constant of activation (tau (a))of presynaptic I(h) current became faster with membrane… CONTINUE READING
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