Hyperpolarization-activated cation channels: from genes to function.

@article{Biel2009HyperpolarizationactivatedCC,
  title={Hyperpolarization-activated cation channels: from genes to function.},
  author={M. Biel and C. Wahl-Schott and S. Michalakis and Xian-gang Zong},
  journal={Physiological reviews},
  year={2009},
  volume={89 3},
  pages={
          847-85
        }
}
  • M. Biel, C. Wahl-Schott, +1 author Xian-gang Zong
  • Published 2009
  • Medicine, Physics
  • Physiological reviews
  • Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the HCN channel family comprises four members (HCN1-4) that are expressed in heart and nervous system. The current produced by HCN channels has been known as I(h) (or I(f) or I(q)). I(h) has also been designated as pacemaker current, because it plays a key role in controlling rhythmic activity of cardiac pacemaker cells and… CONTINUE READING
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