Hyperplasia of epithelium adjacent to transitional cell carcinoma can be induced by growth factors through paracrine pathways

@article{Boer1994HyperplasiaOE,
  title={Hyperplasia of epithelium adjacent to transitional cell carcinoma can be induced by growth factors through paracrine pathways},
  author={Willem de Boer and J. M. J. Rebel and C{\'e}cile M. Thijssen and Marcel Vermey and Th. H. van der Kwast and Adriana J. M. van den Eijnden-van Raaij},
  journal={Virchows Archiv},
  year={1994},
  volume={425},
  pages={439-444}
}
Hyperplasia of transitional cell epithelium adjacent to human transitional cell carcinomas (TCC) is a common finding in pathology. This hyperplasia may be a precancerous aberration. Alternatively, it has been suggested that the hyperplasia is due to paracrine action of tumour-derived growth factors. In this study we tested the latter hypothesis using the mouse tumorigenic TCC cell line NUC-1. Transplantation of NUC-1 tumour cells into the urinary bladder submucosa of syngeneic mice in vivo… CONTINUE READING
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