Hyperplasia of Urinary Tract Epithelium Induced by Continuous Administration of Sulphonamide Derivatives


PAGET (1958) AND WALPOLE (personal communication) found that the administration of 4-ethvlsulphonylnaphthalene-l-sulphonamide (HPA) to rats of their closed random-bred Wistar colony induced hyperplasia of the urinary tract epithelium. The mechanism of its production was not elucidated although it was thought that the phosphatic crystalluria, which resulted… (More)
DOI: 10.1038/bjc.1962.11


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