Hyperplasia as a mechanism for rapid resealing urothelial injuries and maintaining high transepithelial resistance

@article{Vinjar2011HyperplasiaAA,
  title={Hyperplasia as a mechanism for rapid resealing urothelial injuries and maintaining high transepithelial resistance},
  author={Tanja Vi{\vs}njar and Petra Kocbek and Mateja Erdani Kreft},
  journal={Histochemistry and Cell Biology},
  year={2011},
  volume={137},
  pages={177-186}
}
When the urothelial barrier, i.e., the blood−urine barrier, is injured, rapid resealing of the injury is crucial for the normal functioning of the organism. In order to investigate the mechanisms required for rapid resealing of the barrier, we established in vitro models of hyperplastic and normoplastic urothelia. We found that hyperplastic urothelia achieve significantly higher transepithelial resistance (TER) than normoplastic urothelia. However, the expression of cell junctional (claudin-8… CONTINUE READING
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