Hyperphosphorylation of mutant influenza virus matrix protein, M1, causes its retention in the nucleus.

@article{Whittaker1995HyperphosphorylationOM,
  title={Hyperphosphorylation of mutant influenza virus matrix protein, M1, causes its retention in the nucleus.},
  author={Gary R. Whittaker and Iris Kemler and Ari Helenius},
  journal={Journal of virology},
  year={1995},
  volume={69 1},
  pages={439-45}
}
The matrix (M1) protein of influenza virus is a major structural component, involved in regulation of viral ribonucleoprotein transport into and out of the nucleus. Early in infection, M1 is distributed in the nucleus, whereas later, it is localized predominantly in the cytoplasm. Using immunofluorescence microscopy and the influenza virus mutant ts51, we found that at the nonpermissive temperature M1 was retained in the nucleus, even at late times after infection. In contrast, the viral… CONTINUE READING

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