Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.

  title={Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.},
  author={Cathy Andorfer and Yvonne Kress and Marisol Espinoza and R. Erandie Ediriweera De Silva and Kerry Lee Tucker and Yves-Alain Barde and Karen E Duff and Peter Davies},
  journal={Journal of neurochemistry},
  volume={86 3},
Neurofibrillary tangles are composed of insoluble aggregates of the microtubule-associated protein tau. In Alzheimer's disease the accumulation of neurofibrillary tangles occurs in the absence of tau mutations. Here we present mice that develop pathology from non-mutant human tau, in the absence of other exogenous factors, including beta-amyloid. The pathology in these mice is Alzheimer-like, with hyperphosphorylated tau accumulating as aggregated paired helical filaments. This pathologic tau… CONTINUE READING
Highly Influential
This paper has highly influenced 23 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
217 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 217 extracted citations

Similar Papers

Loading similar papers…