Hyperphosphorylated tau is elevated in Alzheimer's disease with psychosis.

  title={Hyperphosphorylated tau is elevated in Alzheimer's disease with psychosis.},
  author={Patrick S. Murray and Caitlin Marie Kirkwood and Megan C Gray and Kenneth N. Fish and Milos D. Ikonomovic and Ronald L. Hamilton and Julia K Kofler and William E. Klunk and Oscar L. Lopez and Robert A. Sweet},
  journal={Journal of Alzheimer's disease : JAD},
  volume={39 4},
Psychosis occurs in 40-60% of Alzheimer's disease (AD) subjects, is heritable, and indicates a more rapidly progressive disease phenotype. Neuroimaging and postmortem evidence support an exaggerated prefrontal cortical synaptic deficit in AD with psychosis. Microtubule-associated protein tau is a key mediator of amyloid-β-induced synaptotoxicity in AD, and differential mechanisms of progressive intraneuronal phospho-tau accumulation and interneuronal spread of tau aggregates have recently been… CONTINUE READING
Highly Cited
This paper has 24 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…