Hyperphosphorylated tau is elevated in Alzheimer's disease with psychosis.

@article{Murray2014HyperphosphorylatedTI,
  title={Hyperphosphorylated tau is elevated in Alzheimer's disease with psychosis.},
  author={Patrick S. Murray and Caitlin Marie Kirkwood and Megan C Gray and Kenneth N. Fish and Milos D. Ikonomovic and Ronald L. Hamilton and Julia K Kofler and William E. Klunk and Oscar L. Lopez and Robert A. Sweet},
  journal={Journal of Alzheimer's disease : JAD},
  year={2014},
  volume={39 4},
  pages={759-73}
}
Psychosis occurs in 40-60% of Alzheimer's disease (AD) subjects, is heritable, and indicates a more rapidly progressive disease phenotype. Neuroimaging and postmortem evidence support an exaggerated prefrontal cortical synaptic deficit in AD with psychosis. Microtubule-associated protein tau is a key mediator of amyloid-β-induced synaptotoxicity in AD, and differential mechanisms of progressive intraneuronal phospho-tau accumulation and interneuronal spread of tau aggregates have recently been… CONTINUE READING
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