Hyperphosphorylated neurofilament NF-H is a serum biomarker of axonal injury.

@article{Shaw2005HyperphosphorylatedNN,
  title={Hyperphosphorylated neurofilament NF-H is a serum biomarker of axonal injury.},
  author={Gerry P.J. Shaw and Cui Hong Yang and Rebecca Ellis and Kevin David Anderson and J Parker Mickle and Stephen William Scheff and Brian John Pike and Douglas K. Anderson and Dena R Howland},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={336 4},
  pages={
          1268-77
        }
}
Several lines of reasoning suggest that the phosphorylated axonal form of the neurofilament subunit NF-H is likely to be released from damaged and diseased neurons in significant amounts. Detection of this protein in serum or CSF might therefore provide information about the presence and degree of neuronal loss. We therefore developed a sensitive NF-H ELISA capable of detecting picogram quantities of phosphorylated NF-H (pNF-H). This assay showed that soluble pNF-H immunoreactivity is readily… CONTINUE READING
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