Hyperphosphatemia aggravates cardiac fibrosis and microvascular disease in experimental uremia.

  title={Hyperphosphatemia aggravates cardiac fibrosis and microvascular disease in experimental uremia.},
  author={Kerstin Amann and Johannes T{\"o}rnig and Birgit Kugel and Marie-Luise Gro\ss and Karin Tyralla and Abdussalam El-Shakmak and Andr{\'a}s Szab{\'o} and Eberhard Ritz},
  journal={Kidney international},
  volume={63 4},
BACKGROUND Hyperphosphatemia is a known predictor of cardiovascular death and specifically of cardiac death in hemodialysis patients. The pathomechanisms involved have not been completely clarified. While a number of observations suggest an important role of hyperphosphatemia and positive calcium balance on atherosclerosis and calcification of the coronary conduit arteries, independent effects on postcoronary microvessels and on cardiac fibrosis have not been excluded. METHODS Male Sprague… CONTINUE READING


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