Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine.

@article{Saller1976HyperphagiaAI,
  title={Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine.},
  author={Charles F. Saller and Edward M. Stricker},
  journal={Science},
  year={1976},
  volume={192 4237},
  pages={385-7}
}
Juvenile male rats given intracerebroventricular injections of 5,7-dihydroxytryptamine, following treatment with desmethylimipramine, maintained body weight gains of 5 to 6 grams per day into adulthood and grew much larger than control rats. Biochemical analyses of brain tissue obtained 50 to 140 days after the injections revealed 60 to 86% depletions of telencephalic 5-hydroxytryptamine, with catecholamine levels unchanged. Hyperphagia did not develop despite comparable losses of 5… CONTINUE READING