Hyperparathyroidism

@article{Fraser2009Hyperparathyroidism,
  title={Hyperparathyroidism},
  author={William D. Fraser},
  journal={The Lancet},
  year={2009},
  volume={374},
  pages={145-158}
}
  • W. Fraser
  • Published 17 July 2009
  • Medicine
  • The Lancet
Hyperparathyroidism is due to increased activity of the parathyroid glands, either from an intrinsic abnormal change altering excretion of parathyroid hormone (primary or tertiary hyperparathyroidism) or from an extrinsic abnormal change affecting calcium homoeostasis stimulating production of parathyroid hormone (secondary hyperparathyroidism). Primary hyperparathyroidism is the third most common endocrine disorder, with the highest incidence in postmenopausal women. Asymptomatic disease is… Expand
85 Citations

Paper Mentions

Observational Patient Registry Clinical Trial
The goal of this study is to: 1. Analyze the expression levels of circulating (serum) miRNAs in primary hyperparathyroidism patients with and without osteoporosis, and patients with… Expand
ConditionsOsteoporosis, Postmenopausal, Primary Hyperparathyroidism
Hyperparathyroidism and Hypoparathyroidism
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A selection of distinct cases of primary hyperparathyroidism due to eutopic and ectopic parathyroid adenomas, as well as a case with a syndromic form of PHPT (multiple endocrine neoplasia type 1), and a cases with FHH type 1 due to a CASR inactivating mutation are presented. Expand
Otoconia degeneration as a consequence of primary hyperparathyroidism.
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Atypical parathyroid adenoma is a tumor that has characteristics both of typicalAdenoma andParathyroid carcinoma and the diagnosis is reached by excluding with strict methods the presence of malignancy criteria. Expand
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Non-parathyroid hypercalcemic conditions as seen in the modern clinic are discussed, with a focus on areas where recent gain of knowledge has been achieved. Expand
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Although rare, recurrent renal SHPT may be caused by a coexistence of both hyperfunctional autograft and SPG after TPTX+FAT, and the 99mTc-sestamibi parathyroid imaging with SPECT/CT is helpful to locate the culprits of recurrent renalSHPT before reoperation. Expand
Postsurgical Evaluation of Secondary Nephrogenic Hyperparathyroidism
TLDR
The convenient surgical removal of the hyperplastic parathyroid gland for postoperative recurrence supports tPTX+AT as the recommended treatment for relevant patients. Expand
Evaluation for Primary Hyperparathyroidism in Patients Who Present With Nephrolithiasis.
TLDR
Patients with serum calcium and PTH values indicating PHP diagnosis may have significant delay to parathyroidectomy, and targeted interventions with electronic health record alerts or automated reflex testing may improve care in this domain. Expand
Screening for primary hyperparathyroidism in a tertiary stone clinic, a useful endeavor
TLDR
Screening for primary hyperparathyroidism in patients evaluated in a tertiary referral setting support screening for 1HPT, and cost savings in screening are realized at 10 years. Expand
Why is primary hyperparathyroidism more severe in children?
TLDR
It is inferred that the GH/IGF-1 axis may be partly responsible for the severe presentation of PHPT in children, given that both GH and IGF-1 are important for the achievement of peak bone mass in young individuals. Expand
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