author={William D. Fraser},
  journal={The Lancet},
Hyperparathyroidism is due to increased activity of the parathyroid glands, either from an intrinsic abnormal change altering excretion of parathyroid hormone (primary or tertiary hyperparathyroidism) or from an extrinsic abnormal change affecting calcium homoeostasis stimulating production of parathyroid hormone (secondary hyperparathyroidism). Primary hyperparathyroidism is the third most common endocrine disorder, with the highest incidence in postmenopausal women. Asymptomatic disease is… Expand
61 Citations

Paper Mentions

Observational Patient Registry Clinical Trial
The goal of this study is to: 1. Analyze the expression levels of circulating (serum) miRNAs in primary hyperparathyroidism patients with and without osteoporosis, and patients with… Expand
ConditionsOsteoporosis, Postmenopausal, Primary Hyperparathyroidism
Pediatric hyperparathyroidism: review and imaging update
The embryology, anatomy, pathophysiology and preoperative localization of parathyroid glands as well as several subtypes of primary familial hyperparathyroidism are reviewed. Expand
A clinical perspective of parathyroid hormone related hypercalcaemia
A selection of distinct cases of primary hyperparathyroidism due to eutopic and ectopic parathyroid adenomas, as well as a case with a syndromic form of PHPT (multiple endocrine neoplasia type 1), and a cases with FHH type 1 due to a CASR inactivating mutation are presented. Expand
Otoconia degeneration as a consequence of primary hyperparathyroidism.
It is suggested that both PTH and total calcium levels affect otolin-1 levels, implying that the calcium dysregulation caused by PHPT may contribute to the otoconia breakdown and may be associated with inner ear disorders such as BPPV. Expand
Atypical parathyroid adenoma: clinical and anatomical pathologic features
Atypical parathyroid adenoma is a tumor that has characteristics both of typicalAdenoma andParathyroid carcinoma and the diagnosis is reached by excluding with strict methods the presence of malignancy criteria. Expand
Unusual recurrent renal secondary hyperparathyroidism caused by hyperplastic autograft with supernumerary parathyroid adenoma
Although rare, recurrent renal SHPT may be caused by a coexistence of both hyperfunctional autograft and SPG after TPTX+FAT, and the 99mTc-sestamibi parathyroid imaging with SPECT/CT is helpful to locate the culprits of recurrent renalSHPT before reoperation. Expand
Postsurgical Evaluation of Secondary Nephrogenic Hyperparathyroidism
The convenient surgical removal of the hyperplastic parathyroid gland for postoperative recurrence supports tPTX+AT as the recommended treatment for relevant patients. Expand
Evaluation for Primary Hyperparathyroidism in Patients Who Present With Nephrolithiasis.
Patients with serum calcium and PTH values indicating PHP diagnosis may have significant delay to parathyroidectomy, and targeted interventions with electronic health record alerts or automated reflex testing may improve care in this domain. Expand
Screening for primary hyperparathyroidism in a tertiary stone clinic, a useful endeavor
Screening for primary hyperparathyroidism in patients evaluated in a tertiary referral setting support screening for 1HPT, and cost savings in screening are realized at 10 years. Expand
Why is primary hyperparathyroidism more severe in children?
It is inferred that the GH/IGF-1 axis may be partly responsible for the severe presentation of PHPT in children, given that both GH and IGF-1 are important for the achievement of peak bone mass in young individuals. Expand
Intraoperative parathormone increase after focused parathyroidectomy in a patient with sarcoidosis – Case report
Wisconsin Criteria with intraoperative parathyroid hormone measured 20 minutes after adenoma removal should be applied in such cases of hypercalcaemia and ostheoporosis in a 63–year -old woman with a history of sarcoidosis and suspected primary hyperparathyroidism. Expand