Hyperoxic reperfusion after global cerebral ischemia promotes inflammation and long-term hippocampal neuronal death.

@article{Hazelton2010HyperoxicRA,
  title={Hyperoxic reperfusion after global cerebral ischemia promotes inflammation and long-term hippocampal neuronal death.},
  author={J. Hazelton and I. Balan and G. Elmer and T. Kristian and R. Rosenthal and G. Krause and T. Sanderson and G. Fiskum},
  journal={Journal of neurotrauma},
  year={2010},
  volume={27 4},
  pages={
          753-62
        }
}
In this study we tested the hypothesis that long-term neuropathological outcome is worsened by hyperoxic compared to normoxic reperfusion in a rat global cerebral ischemia model. Adult male rats were anesthetized and subjected to bilateral carotid arterial occlusion plus bleeding hypotension for 10 min. The rats were randomized to one of four protocols: ischemia/normoxia (21% oxygen for 1 h), ischemia/hyperoxia (100% oxygen for 1 h), sham/normoxia, and sham/hyperoxia. Hippocampal CA1 neuronal… Expand
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