Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension.

@article{Fessel2013HyperoxiaSW,
  title={Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension.},
  author={Joshua Patrick Fessel and Charles Robb Flynn and Linda J. Robinson and Niki L. Penner and Santhi Gladson and Christie J. Kang and David H. Wasserman and Anna R Hemnes and James D. West},
  journal={American journal of respiratory cell and molecular biology},
  year={2013},
  volume={49 5},
  pages={778-87}
}
Pulmonary arterial hypertension (PAH) has been associated with a number of different but interrelated pathogenic mechanisms. Metabolic and oxidative stresses have been shown to play important pathogenic roles in a variety of model systems. However, many of these relationships remain at the level of association. We sought to establish a direct role for metabolic stress and oxidant injury in the pathogenesis of PAH. Mice that universally express a disease-causing mutation in bone morphogenic… CONTINUE READING

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Mitochondrial oxidative stress driven by hyperoxia plays a causative role in BMPR2-mediated pulmonary arterial hypertension

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