Hyperoxia-responsive proteins in rat pulmonary microvascular endothelial cells.

  title={Hyperoxia-responsive proteins in rat pulmonary microvascular endothelial cells.},
  author={Gary A. Visner and Sandra Fogg and Harry S. Nick},
  journal={The American journal of physiology},
  volume={270 4 Pt 1},
Exposure to high partial pressures of oxygen are toxic to the lung, and much of the damage observed is related to injury of the pulmonary microvasculature. In this study, we evaluated the response of the pulmonary microvascular endothelial cell to high oxygen concentrations, using two-dimensional protein gel electrophoresis as a direct molecular assay of differences between cells exposed to room air or hyperoxia. We observed a differential expression of five specific proteins within 24 h of a… CONTINUE READING


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