Hyperoxia-induced signal transduction pathways in pulmonary epithelial cells.

@article{Zaher2007HyperoxiainducedST,
  title={Hyperoxia-induced signal transduction pathways in pulmonary epithelial cells.},
  author={T Entezari Zaher and Edmund J Miller and Dympna M. P. Morrow and Mohammad Javad Javdan and Lin L. Mantell},
  journal={Free radical biology & medicine},
  year={2007},
  volume={42 7},
  pages={897-908}
}
Mechanical ventilation with hyperoxia is necessary to treat critically ill patients. However, prolonged exposure to hyperoxia leads to the generation of excessive reactive oxygen species (ROS), which can cause acute inflammatory lung injury. One of the major effects of hyperoxia is the injury and death of pulmonary epithelium, which is accompanied by increased levels of pulmonary proinflammatory cytokines and excessive leukocyte infiltration. A thorough understanding of the signaling pathways… CONTINUE READING

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