Hyperoxia and salicylate metabolism in rats.

  title={Hyperoxia and salicylate metabolism in rats.},
  author={Michael J. O'Connell and Nigel R. Webster},
  journal={The Journal of pharmacy and pharmacology},
  volume={42 3},
Following the administration of aspirin to rats by gavage, both 2,3- and 2,5-dihydroxybenzoate appeared in the plasma. The concentration of the 2,3-dihydroxybenzoate was significantly higher in animals exposed to 100% O2 for 60 h than in air breathing controls. These data are evidence that increased salicylate hydroxylation is associated with oxidative stress. 

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