Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response.

@article{Thirone2007HyperosmoticSI,
  title={Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response.},
  author={Ana Cl{\'a}udia P. Thirone and Pam Speight and Matthew Zulys and Ori D. Rotstein and Katalin Sz{\'a}szi and Stine Falsig Pedersen and Andr{\'a}s Kapus},
  journal={American journal of physiology. Cell physiology},
  year={2007},
  volume={296 3},
  pages={
          C463-75
        }
}
Hyperosmotic stress induces cytoskeleton reorganization and a net increase in cellular F-actin, but the underlying mechanisms are incompletely understood. Whereas de novo F-actin polymerization likely contributes to the actin response, the role of F-actin severing is unknown. To address this problem, we investigated whether hyperosmolarity regulates cofilin, a key actin-severing protein, the activity of which is inhibited by phosphorylation. Since the small GTPases Rho and Rac are sensitive to… CONTINUE READING

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