Hyperosmotic stress-dependent NFkappaB activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes.

@article{Eisner2006HyperosmoticSN,
  title={Hyperosmotic stress-dependent NFkappaB activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes.},
  author={Ver{\'o}nica Eisner and Alfredo Criollo and Clara Quiroga and Claudio A Olea-Azar and Juan Francisco Santiba{\~n}ez and Rodrigo A. Troncoso and Mario Chiong and Guillermo D{\'i}az-Araya and Rocio E. Foncea and Sergio Lavandero},
  journal={FEBS letters},
  year={2006},
  volume={580 18},
  pages={4495-500}
}
We have recently shown that hyperosmotic stress activates p65/RelB NFkappaB in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death. It remains unexplored how NFkappaB is regulated in cultured rat cardiomyocytes exposed to hyperosmotic stress. We study here: (a) if hyperosmotic stress triggers reactive oxygen species (ROS) generation and in turn whether they regulate NFkappaB and (b) if insulin-like growth factor-1 (IGF-1) modulates ROS production and NFkappaB… CONTINUE READING

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