Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes

@inproceedings{Tew2009HyperosmolarityRS,
  title={Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes},
  author={Simon R Tew and Mandy J Peffers and Tristan R McKay and Emma T. Lowe and Wasim S Khan and Tim E. Hardingham and Peter David Clegg},
  booktitle={American journal of physiology. Cell physiology},
  year={2009}
}
The transcription factor SOX9 regulates cartilage extracellular matrix gene expression and is essential for chondrocyte differentiation. We previously showed that activation of p38 MAPK by cycloheximide in human chondrocytes leads to stabilization of SOX9 mRNA (Tew SR and Hardingham TE. J Biol Chem 281: 39471-39479, 2006). In this study we investigated whether regulation of p38 MAPK caused by changes in osmotic pressure could control SOX9 mRNA levels expression by a similar mechanism. Primary… CONTINUE READING
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