Hyperosmolarity in the small intestine contributes to postprandial ghrelin suppression.


Plasma levels of the orexigenic hormone ghrelin are suppressed by meals with an efficacy dependent on their macronutrient composition. We hypothesized that heterogeneity in osmolarity among macronutrient classes contributes to these differences. In three studies, the impact of small intestinal hyperosmolarity was examined in Sprague-Dawley rats. In study 1… (More)
DOI: 10.1152/ajpgi.00072.2014


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