Hyperosmolarity enhances the lung capillary barrier.

  title={Hyperosmolarity enhances the lung capillary barrier.},
  author={Zeenat Safdar and Ping Wang and Hideo Ichimura and Andrew C. Issekutz and S. P. B. Quadri and Jahar Bhattacharya},
  journal={The Journal of clinical investigation},
  volume={112 10},
Although capillary barrier deterioration underlies major inflammatory lung pathology, barrier-enhancing strategies are not available. To consider hyperosmolar therapy as a possible strategy, we gave 15-minute infusions of hyperosmolar sucrose in lung venular capillaries imaged in real time. Surprisingly, this treatment enhanced the capillary barrier, as indicated by quantification of the capillary hydraulic conductivity. The barrier enhancement was sufficient to block the injurious effects of… CONTINUE READING


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