Hypernuclear acetylation in atherosclerotic lesions and activated vascular smooth muscle cells.

@article{Kawahara1999HypernuclearAI,
  title={Hypernuclear acetylation in atherosclerotic lesions and activated vascular smooth muscle cells.},
  author={Ko-Ichi Kawahara and Shinya Watanabe and Takayuki Ohshima and Yusuke Soejima and Takayuki Oishi and Satoko Aratani and Mitsugu Nakata and Miki Shibata and Ken-Ichi Inoue and Taiju Amano and Ryouji Fujii and Kazuhiko Yanai and Masatoshi Hagiwara and Akiyoshi Fukamizu and Ikuro Maruyama and Tomoki Nakajima},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={266 2},
  pages={417-24}
}
Recent studies have implicated acetylation of several nuclear proteins such as histones and p53 on their epsilon-portion of lysine residues in eukaryotic transcription. Here we raised a specific polyclonal antibody against epsilon-acetylated lysine. Using the antibody, we detected hypernuclear acetylation (HNA) in atherosclerotic vascular smooth muscle cells (VSMCs). Thrombin, a humoral factor known to cause activation and proliferation of VSMCs, strongly potentiated HNA in cultured VSMCs. MAP… CONTINUE READING
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