Hypermutation in derepressed operons of Escherichia coli K12.

  title={Hypermutation in derepressed operons of Escherichia coli K12.},
  author={Barbara E. Wright and Angelika Longacre and Jacqueline M. Reimers},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 9},
This article presents evidence that starvation for leucine in an Escherichia coli auxotroph triggers metabolic activities that specifically target the leu operon for derepression, increased rates of transcription, and mutation. Derepression of the leu operon was a prerequisite for its activation by the signal nucleotide, guanosine tetraphosphate, which accumulates in response to nutritional stress (the stringent response). A quantitative correlation was established between leuB mRNA abundance… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 35 extracted citations

A mechanism of transposon-mediated directed mutation.

Molecular microbiology • 2009
View 10 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-7 of 7 references

Molecular Strategies in Biological Evolution (N.Y

A. Longacre, J. M. Reimers, B. E. Wright
Acad. Sci., • 1999

Wright et al

Weismann, A. Uber die Vererbung. Fischer, Jena, Germany. 5094 Evolution
Proc. Natl. Acad. Sci. USA 96 • 1999

Epigenetic Inheritance and Evolution: The Lamarckian Dimension (Oxford

E. Jablonka, M. J. Lamb

Microorganisms as Model Systems for Studying Evolution

Monographs in Evolutionary Biology • 1984

The Growth of Biological Thought, Diversity, Evolution, and Inheritance (Belknap

E. Mayr

The Origin of Life (Macmillan, New York); trans

A. I. Oparin

Similar Papers

Loading similar papers…