Hypermutation in derepressed operons of Escherichia coli K12.

@article{Wright1999HypermutationID,
  title={Hypermutation in derepressed operons of Escherichia coli K12.},
  author={Barbara E. Wright and Angelika Longacre and Jacqueline M. Reimers},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 9},
  pages={5089-94}
}
This article presents evidence that starvation for leucine in an Escherichia coli auxotroph triggers metabolic activities that specifically target the leu operon for derepression, increased rates of transcription, and mutation. Derepression of the leu operon was a prerequisite for its activation by the signal nucleotide, guanosine tetraphosphate, which accumulates in response to nutritional stress (the stringent response). A quantitative correlation was established between leuB mRNA abundance… CONTINUE READING

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