Hypermutation as a factor contributing to the acquisition of antimicrobial resistance.

@article{Blzquez2003HypermutationAA,
  title={Hypermutation as a factor contributing to the acquisition of antimicrobial resistance.},
  author={Jes{\'u}s Bl{\'a}zquez},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2003},
  volume={37 9},
  pages={1201-9}
}
Contrary to what was thought previously, bacteria seem to be, not merely spectators to their own evolution, but, through a variety of mechanisms, able to increase the rate at which mutations occur and, consequently, to increase their chances of becoming resistant to antibiotics. Laboratory studies and mathematical models suggest that, under stressful conditions, such as antibiotic challenge, selective pressure favors mutator strains of bacteria over nonmutator strains. These hypermutable… CONTINUE READING